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The University Archives houses the historically valuable records of the State University of New York at Buffalo and its predecessor, the University of Buffalo (1846-1962). The Archives collects, organizes and maintains the records of UB academic departments and administrative offices, along with all university and student publications. The Archives also collects the private papers of administrators, faculty members and other individuals associated with UB. Historical manuscript collections complement current or past faculty research interests or document regional organizations and events.

Among the earliest documents housed in the Archives is the Stock Subscription Book, opened in 1846 to secure funds to start the University of Buffalo. Other early records found in the Archives include the minutes of the University Council from 1855 and records of the professional schools which comprised the 19th century University of Buffalo: Medicine, Pharmacy, Law and Dentistry. Today, with holdings that occupy more than 5,000 linear feet, the University Archives registers the many changes in American higher education over the past 165 years.